Research Highlights


Biomedical Imaging


A) State-of-the-Art


Advanced development in medical imaging and bio-electronic instrumentations

The medical imaging planning software for surgical planning in oral and maxillofacial regions and dual mode 3D body scanning/motion tracking module, including 3D calibration, feature points identification and lines of the body, construction of digital human model structure are leading globally. Some advanced technologies include 1) development of the novel acoustic tweezers using high-frequency ultrasound sensor for cell manipulation, cell cutting and force sensing in collaboration with Professor K. Kirk Shung, South California University, 2) design of a three-dimensional magnetic navigation system for cancer therapy using targeted nanoparticles and endoscopy treatments, and 3) development of breast MRI/PET systems for cancer diagnosis.



B) Executive Project


(1) Apply Navigation Planning in Orthognathic Surgery to Correct Facial Asymmetry and Complex Facial Disharmonies

      PIFang, Jing-Jing ; Professor; Department of Mechanical Engineering, National Cheng Kung University 
      Co-PIWong, Tung-Yiu ; Associate Professor; Institute of Oral Medicine, National Cheng Kung University 
      Co-PILiu, Jia-Kuang ; Associate Professor; Institute of Oral Medicine, National Cheng Kung University
      Co-PI:Chen, Kern-Chung; Doctor; Dental Department; National Cheng Kung University Hospital



There are some degrees of inaccuracy in the orthognathic surgery practice. Some of them are related to the planning and prediction methods. While the combined paper surgery and the model surgery method work quite well in simple cases, the prediction is not constantly precise in complex cases, especially in the treatment of facial bone asymmetry. A gap exists between the paper surgery and the model surgery in that they are neither mutually registered nor synchronized. We have developed a new tool- the navigational model surgery, to assist treatment planning in orthognathic surgery. Using an optical tracking system, the movement of the jawbones can be viewed and the position be examined simultaneously in the computer during the model surgery. The symmetry status of the relocated skeleton can also be evaluated using a self-developed symmetry analysis program.

The aims of this study are 1. To discover the merits of using navigation in planning orthognathic surgery in practice; 2. To determine which kinds of deformity or surgery are most benefitted from the navigational planning; and 3. To develop an appropriate platform to integrate the hardware and the software for navigational planning. Thirty cases of asymmetry and 30 cases of non-asymmetry facial disharmony that require surgical correction are recruited and received the navigational planning. The merits of the new planning method, the feasibility of the new planning platform, the accuracy of the prediction, and the overall surgical outcome will be compared to the groups using the traditional planning method. The project was partially supported by Medical Device Innovation Center of NCKU, including the follow-up processes correlated with patenting, technology transferring, and marketing. It is to be assured that the novel integrated navigational product for orthognathic surgical planning will be quickly accepted by the healthcare market.



Figure 1 illustrates the novel model surgical planning system. Through the dental cast movements controlled by surgeon, new positions of the maxilla and mandible are exposed accordingly via the tracking device. Combining the patented symmetry analysis method, the integrated system can assist surgeons to locate a predicable compromised positioning toward the goals of facial symmetry, harmony, and occlusion.


Figure 1. Navigational model surgical planning for orthognathic surgery


Figure 2(a) and (b) depict pre- and post-surgery of one of more than thirty successful cases that employed the techniques. The patient was diagnosed Hemifacial microsomia – a complex facial disharmony and asymmetry case, difficult for planning. More information can be found in the NCKUH orthognathic surgery center



Figure 2. (a) pre-, (b) post-orthognathic surgery by applying our planning




(2) Development of New-Generation PET/MRI for Breast Cancer

      PI:Ming-Shing Young , Distinguished Professor, Department of Electrical Engineering, NCKU 

      Co-PI:Wei-Jen Yao , Department of Nuclear Medicine, College of Medicine, NCKU



In this project, NCKU and BNL collectively expect to develop a new-generation PET which included: 1) The current generation of the Micro PET (single-ring and four-ring PET) design and application must be technology transfer from BNL to NCKU. Furthermore, a single and four ring Micro PET are installed in a breast MRI system to allow simultaneous imaging of PET and MRI for breast cancer patients; 2) Develop the next generation of PET/MRI (Multi-ring SiPM PET) by NCKU with technical support from BNL. Cooperate with Aurora to develop new-generation PET/BMRI and PET/MRI.

Fig. 1 Rat Conscious Animal PET (BNL)

Fig. 2 Spatial resolution of PET

Fig. 3 Current and next generation PET detectors