Research Highlights

 Orthopedic medical device

 

A) State-of-the-art

 

Leading Orthopaedic Devices R&D:

It is generally accepted that metallic implant materials with higher strength/modulus ratios are more favorable due to a combined effect of high strength and reduced stress-shielding risk. Recently, two high strength, low modulus (Ti-Mo alloy with modulus of 67GPa which is 40% lower than that of the current marketed Ti alloy (110 GPa), Al/V-free (morebiocompatible) Ti alloy systems (α” type Ti-Mo and β type Ti-Mo-Bi) with strength/modulus ratios higher than any existing implantable Ti alloy have been developed in the laboratory by the current PI and the research team. Animal study indicates a much faster healing process. Another noteworthy implant material developed in-house by the materials/surgeons team is a series of non-dispersive calcium phosphate-based orthopedic cements and other forms of bone substitutes. This orthopedic cement has overcome the challenge that most commercial products are facing: being dispersed upon contact with body fluid/blood during or after surgery, which may cause serious complications. 2+ years of the clinical trials of 30+ patients demonstrates a 96% success rate using this newly developed calcium phosphate-based cement for vertebroplasty treatment. This first-generation CPC product has been approved by the Department of Health (DOH), Executive Yuan Clinical Study Evaluation Committee for vertebroplasty application (衛署醫字第0960045775號). 


Other leading or potentially leading technologies of the Center include the design and development of: BMP-impregnated bioresorbable orthopedic cement to enhance bone formation for vertebroplasty; guiding blocks for accurate insertion of transpedicular screws for cervical, thoracic and lumbar spine applications; guiding jigs for vertebroplasty; facet joints for fusion and arthroplasty; semi-rigid instrumentation of the lumbar spine to decrease the adjacent segment mobility and degeneration; non-fusion devices; shoulder prosthesis/fixators; total ankle, thumb carpometacarpal prosthesis and finger joint prosthesis; implants for hip fractures; wear-resistant total knee prosthesis.

 


 

B) Executive Project

             

             PI:Jiin-Huey Chern Lin ; Professor, Department of Materials Science and Engineering, NCKU 
             Co-PI:Chien-Ping Ju ; Professor, Department of Materials Science and Engineering, NCKU
             Co-PI: Ching-Wei Lee ; Associated Professor, Department of Surgery, NCKU